Over the last decade, studies have linked the beneficial effect of pomegranate juice on glycemic control. They have a significant secretory influence on beta-cell, carbohydrate, and lipid metabolism turnover in preventing and treating type ii diabetes. However, hypoglycaemic drugs have side effects such as lactic acidosis and abdominal discomfort. Hence, we aimed for a new treatment regime that included oral antidiabetic drugs and pomegranate juice, which works as an anti-oxidant and a potential antidiabetic agent. The study included randomly chosen145 type 2 diabetes mellitus male subjects and 36 healthy male participants. The study was carried out in two stages. Initially, all subjects were allowed to be on their respective antidiabetic drugs/insulin and to have a regular check-up of blood glucose twice a week for four weeks, after which they were redistributed into three groups, one of which was given pomegranate juice along with their respective antidiabetic drugs. After a 4-week run-in period, patients improved their ability to self-monitor blood glucose values and a wash-out period of 3 weeks, during which oral hypoglycaemic drugs and insulin were discontinued. The subjects were randomly assigned to follow the treatment protocol. Subjects received either an antidiabetic medicine or insulin, while the others received 200 ml of pomegranate fruit juice every day, along with antidiabetic therapy assigned to two-month treatment intervals. Glycemic rate and lipid profile changes were observed at the end of the period. The subjects with Pomegranate Juice with drug treatment showed a significant reduction in the levels of HbAlc (6.2 ± 0.2% vs. 8.2 ± 0.3%.)), LDL cholesterol concentration (120.61 ± 12.81, vs 136.23 ± 16.58 mg/dl P < 0.05), and Phospotidyl choline (27.20 ± 1.98 vs 22.80 ± 2.20 mg/cc. P < 0.05 as compared to other groups. This study has observed that pomegranate juice combined with an antidiabetic therapy regime has outstanding potential advantages in glucose control and a significant reduction in dyslipidemia and increased phospholipids levels compared to insulin or drug alone. These changes are linked to disease progression in numerous tissues. Pomegranate juice therapy may lower the need for diabetic medication or insulin, and natural diet fruits may impact pancreatic cell activation.