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Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives

Food Science and Biotechnology (2023)Cite this article

Abstract

The diverse populations reportedly suffer from obesity on a global scale, and inconclusive evidence has indicated that both environmental and genetic factors are associated with obesity development. Therefore, a need exists to examine potential therapeutic or prophylactic molecules for obesity treatment. Prebiotics with non-digestible oligosaccharides (NDOs) have the potential to treat obesity. A limited number of prebiotic NDOs have demonstrated their ability as a convincing therapeutic solution to encounter obesity through various mechanisms, viz., stimulating beneficial microorganisms, reducing the population of pathogenic microorganisms, and also improving lipid metabolism and glucose homeostasis. NDOs include pectic-oligosaccharides, fructo-oligosaccharides, xylo-oligosaccharides, isomalto-oligosaccharides, manno-oligosaccharides and other oligosaccharides which significantly influence the overall human health by different mechanisms. This review provides the treatment of obesity benefits by incorporating these prebiotic NDOs, according to established scientific research, which shows their good effects extend beyond the colon.

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References

  • Aachary AA, Prapulla SG. Xylooligosaccharides (XOS) as an emerging prebiotic: microbial synthesis, utilization, structural characterization, bioactive properties, and applications. Comprehensive Reviews in Food Science and Food Safety. 10: 2-16 (2011)

    Article  CAS  Google Scholar 

  • Abenavoli L, Scarpellini E, Colica C, Boccuto L, Salehi B, Sharifi-Rad J, Aiello V, Romano B, De Lorenzo A, Izzo AA, Capasso R. Gut microbiota and obesity: a role for probiotics. Nutrients 11: 2690 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alderete TL, Autran C, Brekke BE, Knight R, Bode L, Goran MI, Fields DA. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life. The American Journal of Clinical Nutrition. 102: 1381-13888 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ang Z, Ding JL. GPR41 and GPR43 in obesity and inflammation–protective or causative?. Frontiers in Immunology 7: 28 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  • Arora V, Sachdeva AK, Singh P, Baveja A, Chopra K, Kuhad A. Resveratrol and lycopene in the diet and cancer prevention. InCancer. pp. 127–138. Academic Press (2014).

  • Babbar N, Dejonghe W, Gatti M, Sforza S, Elst K. Pectic oligosaccharides from agricultural by-products: production, characterization and health benefits. Critical Reviews in Biotechnology. 36: 594-606 (2016)

    Article  CAS  PubMed  Google Scholar 

  • Beisner J, Filipe Rosa L, Kaden-Volynets V, Stolzer I, Günther C, Bischoff SC. Prebiotic inulin and sodium butyrate attenuate obesity-induced intestinal barrier dysfunction by induction of antimicrobial peptides. Frontiers in Immunology. 12: 678360 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bindels LB, Delzenne NM, Cani PD, Walter J. Towards a more comprehensive concept for prebiotics. Nature reviews Gastroenterology & Hepatology. 12: 303-310 (2015)

    Article  CAS  Google Scholar 

  • Boets E, Gomand SV, Deroover L, Preston T, Vermeulen K, De Preter V, Hamer HM, Van den Mooter G, De Vuyst L, Courtin CM, Annaert P. Systemic availability and metabolism of colonic‐derived short‐chain fatty acids in healthy subjects: a stable isotope study. The Journal of Physiology. 595: 541-555 (2017)

    Article  CAS  PubMed  Google Scholar 

  • Brooks L, Viardot A, Tsakmaki A, Stolarczyk E, Howard JK, Cani PD, Everard A, Sleeth ML, Psichas A, Anastasovskaj J, Bell JD. Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Molecular Metabolism. 6: 48-60. (2017)

    Article  CAS  PubMed  Google Scholar 

  • Byrne CS, Chambers ES, Morrison DJ, Frost G. The role of short chain fatty acids in appetite regulation and energy homeostasis. International Journal of Obesity. 39: 1331-1338 (2015)

    Article  CAS  PubMed  Google Scholar 

  • Camacho S, Michlig S, de Senarclens-Bezençon C, Meylan J, Meystre J, Pezzoli M, Markram H, Le Coutre J. Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Scientific Reports. 5: 7919 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Canfora EE, van der Beek CM, Hermes GD, Goossens GH, Jocken JW, Holst JJ, van Eijk HM, Venema K, Smidt H, Zoetendal EG, Dejong CH. Supplementation of diet with galacto-oligosaccharides increases bifidobacteria, but not insulin sensitivity, in obese prediabetic individuals. Gastroenterology. 153: 87-97 (2017)

    Article  CAS  PubMed  Google Scholar 

  • Cerdó T, García-Santos JA, G. Bermúdez M, Campoy C. The role of probiotics and prebiotics in the prevention and treatment of obesity. Nutrients. 15, 11: 635 (2019)

  • Chaiyasut C, Sivamaruthi BS, Kesika P, Khongtan S, Khampithum N, Thangaleela S, Peerajan S, Bumrungpert A, Chaiyasut K, Sirilun S, Sittiprapaporn P. Synbiotic supplementation improves obesity index and metabolic biomarkers in Thai obese adults: A randomized clinical trial. Foods. 10: 1580 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chavez JA, Summers SA. A ceramide-centric view of insulin resistance. Cell metabolism. 15: 585-594 (2012)

    Article  CAS  PubMed  Google Scholar 

  • Cleophas MC, Ratter JM, Bekkering S, Quintin J, Schraa K, Stroes ES, Netea MG, Joosten LA. Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males. Scientific Reports. 9: 1-0 (2019)

    Article  CAS  Google Scholar 

  • Coppola S, Avagliano C, Calignano A, Berni Canani R. The protective role of butyrate against obesity and obesity-related diseases. Molecules. 26: 682 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cox LM, Blaser MJ. Antibiotics in early life and obesity. Nature Reviews Endocrinology. 11: 182-190 (2015)

    Article  PubMed  Google Scholar 

  • Dahiya DK, Puniya M, Shandilya UK, Dhewa T, Kumar N, Kumar S, Puniya AK, Shukla P. Gut microbiota modulation and its relationship with obesity using prebiotic fibers and probiotics: a review. Frontiers in Microbiology. 8: 563 (2017)

    Article  PubMed  PubMed Central  Google Scholar 

  • Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota–gut–brain communication. Nature reviews Gastroenterology & Hepatology. 16: 461-478. (2019)

    Article  Google Scholar 

  • Delannoy-Bruno O, Desai C, Raman AS, Chen RY, Hibberd MC, Cheng J, Han N, Castillo JJ, Couture G, Lebrilla CB, Barve RA. Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans. Nature. 595: 91-95 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Delzenne NM, Neyrinck AM, Bäckhed F, Cani PD. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nature Reviews in Endocrinology. 7: 639-646 (2011)

    Article  CAS  PubMed  Google Scholar 

  • Den Besten G, Van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 54: 2325-2340 (2013)

    Article  Google Scholar 

  • Den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM. Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes. 64: 2398-2408 (2015)

    Article  Google Scholar 

  • Dewulf EM, Cani PD, Neyrinck AM, Possemiers S, Van Holle A, Muccioli GG, Deldicque L, Bindels LB, Pachikian BD, Sohet FM, Mignolet E. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry. 22: 712-722 (2021)

    Article  Google Scholar 

  • Divyashri G, Sadanandan B, Chidambara Murthy KN, Shetty K, Mamta K. Neuroprotective Potential of Non-Digestible Oligosaccharides: An Overview of Experimental Evidence. Frontiers in Pharmacology. 12: 712531 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fang W, Xue H, Chen X, Chen K, Ling W. Supplementation with sodium butyrate modulates the composition of the gut microbiota and ameliorates high-fat diet-induced obesity in mice. The Journal of Nutrition. 149: 747-54 (2019)

    Article  PubMed  Google Scholar 

  • Fei Y, Wang Y, Pang Y, Wang W, Zhu D, Xie M, Lan S, Wang Z. Xylooligosaccharide modulates gut microbiota and alleviates colonic inflammation caused by high fat diet induced obesity. Frontiers in Physiology. 10: 1601 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  • Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González Á, Esquivel-Chirino C, Durante-Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA. Inflammation, oxidative stress, and obesity. International journal of molecular sciences. 12: 3117-3132 (2011)

    Article  PubMed  PubMed Central  Google Scholar 

  • Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M, Colecchia A. Gut microbiota and metabolic syndrome. World Journal of Gastroenterology. 20: 16079 (2014)

    Article  PubMed  PubMed Central  Google Scholar 

  • Fonvig CE, Amundsen ID, Vigsnæs LK, Sørensen N, Frithioff-Bøjsøe C, Christiansen M, Hedley PL, Holm LA, McConnell B, Holm JC. Human milk oligosaccharides modulate fecal microbiota and are safe for use in children with overweight: a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition. 73: 408-414 (2021)

    Article  CAS  PubMed  Google Scholar 

  • Goh YJ, Klaenhammer TR. Genetic mechanisms of prebiotic oligosaccharide metabolism in probiotic microbes. Annual Review of Food Science and Technology. 6: 137-156 (2015)

    Article  CAS  PubMed  Google Scholar 

  • Grembi JA, Nguyen LH, Haggerty TD, Gardner CD, Holmes SP, Parsonnet J. Gut microbiota plasticity is correlated with sustained weight loss on a low-carb or low-fat dietary intervention. Scientific Reports. 10: 1-4 (2020)

    Google Scholar 

  • Guo M, Chen G, Chen K. Fructooligosaccharides: Effects, mechanisms, and applications. In: Yin H, Du Y (eds) Research progress in oligosaccharins. Springer, New York, NY (2016). https://doi.org/10.1007/978-1-4939-3518-5_5

  • Hadi A, Sepandi M, Marx W, Moradi S, Parastouei K. Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial. Complementary Therapies in Medicine. 47: 102216 (2019)

    Article  PubMed  Google Scholar 

  • Henagan TM, Stefanska B, Fang Z, Navard AM, Ye J, Lenard NR, Devarshi PP. Sodium butyrate epigenetically modulates high‐fat diet‐induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning. British Journal of Pharmacology. 172: 2782-2798 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holck J, Hotchkiss Jr AT, Meyer AS, Mikkelsen JD, Rastall RA. Production and bioactivity of pectic oligosaccharides from Fruit and Vegetable biomass. Food Oligosaccharides: Production, analysis and bioactivity. 76–87 (2014). https://doi.org/10.1002/9781118817360.ch5

  • Hong J, Jia Y, Pan S, Jia L, Li H, Han Z, Cai D, Zhao R. Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice. Oncotarget. 7: 56071 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang L, Chen J, Cao P, Pan H, Ding C, Xiao T, Zhang P, Guo J, Su Z. Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats. Marine Drugs. 13: 2732-2756 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hume MP, Nicolucci AC, Reimer RA. Prebiotic supplementation improves appetite control in children with overweight and obesity: a randomized controlled trial. The American Journal of Clinical Nutrition. 105: 790-799 (2017)

    Article  CAS  PubMed  Google Scholar 

  • Jain I, Kumar V, Satyanarayana T. Xylooligosaccharides: an economical prebiotic from agroresidues and their health benefits. Indian Journal of Experimental Biology 53: 131-142 (2015)

    Google Scholar 

  • Jana UK, Kango N, Pletschke B. Hemicellulose-derived oligosaccharides: emerging prebiotics in disease alleviation. Frontiors in Nutition. 8: 670817 (2021)

    Google Scholar 

  • Jia Y, Hong J, Li H, Hu Y, Jia L, Cai D, Zhao R. Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation‐associated β3‐adrenergic receptor activation in high‐fat diet‐induced obese mice. Experimental Physiology. 102: 273-281 (2017)

    Article  PubMed  Google Scholar 

  • Jiao A, Yu B, He J, Yu J, Zheng P, Luo Y, Luo J, Yan H, Wang Q, Wang H, Mao X. Sodium acetate, propionate, and butyrate reduce fat accumulation in mice via modulating appetite and relevant genes. Nutrition. 87: 111198 (2021)

    Article  PubMed  Google Scholar 

  • Khan MJ, Gerasimidis K, Edwards CA, Shaikh MG. Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature. Journal of Obesity. (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  • Khare P, Jagtap S, Jain Y, Baboota RK, Mangal P, Boparai RK, Bhutani KK, Sharma SS, Premkumar LS, Kondepudi KK, Chopra K. Cinnamaldehyde supplementation prevents fasting‐induced hyperphagia, lipid accumulation, and inflammation in high‐fat diet‐fed mice. Biofactors. 42: 201-211 (2016)

    Article  CAS  PubMed  Google Scholar 

  • Kianifar HR, Ahanchian H, Safarian M, Javid A, Farsad-Naeimi A, Jafari SA, Dahri M. Effects of synbiotics on anthropometric indices of obesity in children. Topics in Clinical Nutrition. 33: 118-126 (2018)

    Article  Google Scholar 

  • Krumbeck JA, Rasmussen HE, Hutkins RW, Clarke J, Shawron K, Keshavarzian A, Walter J. Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics. Microbiome. 6: 1-6 (2018)

    Article  Google Scholar 

  • Lee JY, Kim TY, Kang H, Oh J, Park JW, Kim SC, Kim M, Apostolidis E, Kim YC, Kwon YI. Anti-obesity and anti-adipogenic effects of chitosan oligosaccharide (GO2KA1) in SD rats and in 3T3-L1 preadipocytes models. Molecules. 26: 331 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JF, Heijink M. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut. 67: 1269-1279 (2018)

    Article  CAS  PubMed  Google Scholar 

  • Li R, Yuan X, Wei J, Zhang X, Cheng G, Wang ZA, Du Y. Synthesis and evaluation of a chitosan oligosaccharide-streptomycin conjugate against Pseudomonas aeruginosa biofilms. Marine Drugs. 17: 43 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liber A, Szajewska H. Effect of oligofructose supplementation on body weight in overweight and obese children: a randomised, double-blind, placebo-controlled trial. British Journal of Nutrition. 112: 2068-2074 (2014)

    Article  CAS  PubMed  Google Scholar 

  • Licciardi PV, Ververis K, Karagiannis TC. Histone deacetylase inhibition and dietary short-chain fatty acids. International Scholarly Research Notices. (2011)

    Article  Google Scholar 

  • Lin HV, Frassetto A, Kowalik Jr EJ, Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PloS one. 7: e35240 (2012)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liong MT, Dunshea FR, Shah NP. Effects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high-and low-fat diets. British Journal of Nutrition. 98: 736-744 (2007)

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Chen J, Tan Q, Deng X, Tsai PJ, Chen PH, Ye M, Guo J, Su Z. Non-digestible oligosaccharides with anti-obesity effects. Journal of Agricultural and Food Chemistry. 68: 4-16 (2019)

    Article  PubMed  Google Scholar 

  • Lockyer S, Stanner S. Prebiotics–an added benefit of some fibre types. Nutrition Bulletin. 44: 74-91 (2019)

    Article  Google Scholar 

  • Long J, Yang J, Henning SM, Woo SL, Hsu M, Chan B, Heber D, Li Z. Xylooligosaccharide supplementation decreases visceral fat accumulation and modulates cecum microbiome in mice. Journal of Functional Foods. 52: 138-146 (2019)

    Article  CAS  Google Scholar 

  • Lu Y, Fan C, Li P, Lu Y, Chang X, Qi K. Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota. Scientific Reports. 6: 37589 (2016)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mamo G, Faryar R, Karlsson EN. Microbial glycoside hydrolases for biomass utilization in biofuels applications. Biofuel technologies: Recent Developments. 171-188 (2013)

    Google Scholar 

  • Mazloom K, Siddiqi I, Covasa M. Probiotics: how effective are they in the fight against obesity?. Nutrients 11:258 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meyer D. Health benefits of prebiotic fibers. Advances in Food and Nutrition Research. 74: 47-91 (2015)

    Article  CAS  PubMed  Google Scholar 

  • Michael DR, Jack AA, Masetti G, Davies TS, Loxley KE, Kerry-Smith J, Plummer JF, Marchesi JR, Mullish BH, McDonald JA, Hughes TR. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Scientific Reports. 10: 4183 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Michael DR, Davies TS, Jack AA, Masetti G, Marchesi JR, Wang D, Mullish BH, Plummer SF. Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults. Scientific Reports. 11: 5 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mitmesser S, Combs M. Prebiotics: Inulin and other oligosaccharides. In: The microbiota in gastrointestinal pathophysiology, pp. 201–208. Academic Press (2017). https://doi.org/10.1016/B978-0-12-804024-9.00023-9

  • Mussatto SI, Mancilha IM. Non-digestible oligosaccharides: A review. Carbohydrate Polymers. 68: 587-597 (2007)

    CAS  Google Scholar 

  • Neyrinck AM, Van Hee VF, Piront N, De Backer F, Toussaint O, Cani PD, Delzenne NM. Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice. Nutrition & Diabetes. 2: 28 (2012)

    Article  Google Scholar 

  • Nicolucci AC, Hume MP, Martínez I, Mayengbam S, Walter J, Reimer RA. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 153: 711-722. (2017)

    Article  PubMed  Google Scholar 

  • Nie Q, Chen H, Hu J, Tan H, Nie S, Xie M. Effects of non-digestible oligosaccharides on obesity. Annual Review of Food Science and Technology. 11: 205-233 (2020)

    Article  CAS  PubMed  Google Scholar 

  • Pan H, Fu C, Huang L, Jiang Y, Deng X, Guo J, Su Z. Anti-obesity effect of chitosan oligosaccharide capsules (COSCs) in obese rats by ameliorating leptin resistance and adipogenesis. Marine Drugs. 16: 198 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  • Panee J. Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes. Cytokine. 60: 1-2 (2012)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Psichas A, Sleeth ML, Murphy KG, Brooks L, Bewick GA, Hanyaloglu AC, Ghatei MA, Bloom SR, Frost G. The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. International Journal of Obesity. 39: 424-429 (2015)

    Article  CAS  PubMed  Google Scholar 

  • Rastall RA. Functional oligosaccharides: application and manufacture. Annual Review of Food Science and Technology. 1: 305-339 (2010)

    Article  CAS  PubMed  Google Scholar 

  • Reimer RA, Willis HJ, Tunnicliffe JM, Park H, Madsen KL, Soto‐Vaca A. Inulin‐type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: a randomized controlled trial. Molecular Nutrition & Food Research. 61: 1700484 (2017)

    Article  Google Scholar 

  • Respondek F, Myers K, Smith TL, Wagner A, Geor RJ. Dietary supplementation with short-chain fructo-oligosaccharides improves insulin sensitivity in obese horses. Journal of Animal Science. 89: 77-83 (2011)

    Article  CAS  PubMed  Google Scholar 

  • Rico X, Gullon B, Alonso JL, Parajó JC, Yanez R. Valorization of peanut shells: Manufacture of bioactive oligosaccharides. Carbohydrate Polymers. 183: 21-8 (2018)

    Article  CAS  PubMed  Google Scholar 

  • Sergeev IN, Aljutaily T, Walton G, Huarte E. Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients. 12: 222 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • She J, Wong CC, Yu J. Targeted prebiotics alter the obese gut microbiome in humans. Signal Transduction and Targeted Therapy. 6: 363 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  • Shon J, Park YJ. Effects of Dietary Butyrate on Diet-Induced Obesity and Lipid Metabolism. Current Developments in Nutrition. 525 (2021)

    Article  PubMed Central  Google Scholar 

  • Singh DP, Khare P, Zhu J, Kondepudi KK, Singh J, Baboota RK, Boparai RK, Khardori R, Chopra K, Bishnoi M. A novel cobiotic-based preventive approach against high-fat diet-induced adiposity, nonalcoholic fatty liver and gut derangement in mice. International Journal of Obesity. 40: 487-496 (2016)

    Article  CAS  PubMed  Google Scholar 

  • Singh DP, Khare P, Bijalwan V, Baboota RK, Singh J, Kondepudi KK, Chopra K, Bishnoi M. Coadministration of isomalto‐oligosaccharides augments metabolic health benefits of cinnamaldehyde in high fat diet fed mice. BioFactors. 43: 821-835 (2017a)

  • Singh DP, Singh J, Boparai RK, Zhu J, Mantri S, Khare P, Khardori R, Kondepudi KK, Chopra K, Bishnoi M. Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice. Pharmacological Research. 123: 103-113 (2017b)

  • Singh DP, Singh S, Bijalwan V, Kumar V, Khare P, Baboota RK, Singh P, Boparai RK, Singh J, Kondepudi KK, Chopra K. Co-supplementation of isomalto-oligosaccharides potentiates metabolic health benefits of polyphenol-rich cranberry extract in high fat diet-fed mice via enhanced gut butyrate production. European Journal of Nutrition. 57: 2897-2911 (2018)

    Article  CAS  PubMed  Google Scholar 

  • Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutrition and Health. 23: 75-81 (2017)

    Article  CAS  PubMed  Google Scholar 

  • Smith Jr DL, Nagy TR, Wilson LS, Dong S, Barnes S, Allison DB. The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice. Obesity. 18: 995-999 (2010)

    Article  CAS  PubMed  Google Scholar 

  • Sorndech W, Nakorn KN, Tongta S, Blennow A. Isomalto-oligosaccharides: recent insights in production technology and their use for food and medical applications. LWT. 95: 135-142 (2018)

    Article  CAS  Google Scholar 

  • Stenman LK, Lehtinen MJ, Meland N, Christensen JE, Yeung N, Saarinen MT, Courtney M, Burcelin R, Lähdeaho ML, Linros J, Apter D. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults-randomized controlled trial. EBioMedicine 13: 190–200 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  • Stilling RM, van de Wouw M, Clarke G, Stanton C, Dinan TG, Cryan JF. The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?. Neurochemistry International. 99: 110-132 (2016)

    Article  CAS  PubMed  Google Scholar 

  • St‐Onge MP, Salinardi T, Herron‐Rubin K, Black RM. A weight‐loss diet including coffee‐derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women. Obesity. 20: 343-348 (2012)

    Article  CAS  PubMed  Google Scholar 

  • Tengeler AC, Gart E, Wiesmann M, Arnoldussen IA, van Duyvenvoorde W, Hoogstad M, Dederen PJ, Verweij V, Geenen B, Kozicz T, Kleemann R. Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr−/−. Leiden mice. Faseb Journal. 34: 9575-9593 (2020)

    Article  CAS  PubMed  Google Scholar 

  • Thiennimitr P, Yasom S, Tunapong W, Chunchai T, Wanchai K, Pongchaidecha A, Lungkaphin A, Sirilun S, Chaiyasut C, Chattipakorn N, Chattipakorn SC. Lactobacillus paracasei HII01, xylooligosaccharides, and synbiotics reduce gut disturbance in obese rats. Nutrition. 54: 40-47 (2018)

    Article  CAS  PubMed  Google Scholar 

  • Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science Translational Medicine. 24;11 (2019)

    Article  PubMed  Google Scholar 

  • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 444: 1027-1031 (2006)

    Article  PubMed  Google Scholar 

  • Vera C, Illanes A, Guerrero C. Enzymatic production of prebiotic oligosaccharides. Current Opinion in Food Science. 37: 160-170 (2021)

    Article  CAS  Google Scholar 

  • Verhoef SP, Meyer D, Westerterp KR. Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake. British Journal of Nutrition. 106: 1757-1762 (2011)

    Article  CAS  PubMed  Google Scholar 

  • Wanchai K, Yasom S, Tunapong W, Chunchai T, Thiennimitr P, Chaiyasut C, Pongchaidecha A, Chatsudthipong V, Chattipakorn S, Chattipakorn N, Lungkaphin A. Prebiotic prevents impaired kidney and renal Oat3 functions in obese rats. Journal of Endocrinology. 237: 29-42 (2018)

    Article  CAS  PubMed  Google Scholar 

  • Wang D, Liu CD, Li HF, Tian ML, Pan JQ, Shu G, Jiang QY, Yin YL, Zhang L. LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. Metabolism. 102: 154011 (2020)

    Article  CAS  PubMed  Google Scholar 

  • Wen JJ, Gao H, Hu JL, Nie QX, Chen HH, Xiong T, Nie SP, Xie MY. Polysaccharides from fermented Momordica charantia ameliorate obesity in high-fat induced obese rats. Food & Function. 10: 448-457 (2019)

    Article  CAS  Google Scholar 

  • WHO Consultation on Obesity (1999: Geneva S and Organization WH. Obesity : preventing and managing the global epidemic : report of a WHO consultation (2000)

  • Yan S, Shi R, Li L, Ma S, Zhang H, Ye J, Wang J, Pan J, Wang Q, Jin X, Liu X. Mannan oligosaccharide suppresses lipid accumulation and appetite in western‐diet‐induced obese mice via reshaping gut microbiome and enhancing short‐chain fatty acids production. Molecular Nutrition & Food Research. 63: 1900521 (2019)

    Article  CAS  Google Scholar 

  • Zhang C, Abdo AA, Kaddour B, Wu Q, Xin L, Li X, Fan G, Teng C. Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice. Journal of Functional Foods. 64: 103622 (2020)

    Article  CAS  Google Scholar 

  • Zmora N, Suez J, Elinav E. You are what you eat: diet, health and the gut microbiota. Nature reviews Gastroenterology & Hepatology. 16: 35-56 (2019)

    Article  CAS  Google Scholar 

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Acknowledgements

DG greatly appreciates the support provided by the Management and the Principal of M S Ramaiah Institute of Technology, Bangalore, India, while writing the manuscript.

Funding

No funding was obtained for this study.

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Authors and Affiliations

  1. Department of Biotechnology, M S Ramaiah Institute of Technology, Bengaluru, 560 054, India

    G. Divyashri, T. P. Krishna Murthy & Dey Priyadarshini

  2. Department of Food Technology, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, 641 021, India

    Pothiyappan Karthik

  3. School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia

    Kakarla Raghava Reddy

  4. Faculty of Allied Health Sciences, BLDE (Deemed-to-Be University), Vijayapura, 586103, Karnataka, India

    Anjanapura V. Raghu

  5. Department of Biotechnology, School of Bioengineering, Integrated Bioprocessing Laboratory, SRM Institute of Science and Technology (SRM IST), 603 203, Kattankulathur, India

    Vinoth Kumar Vaidyanathan

Authors
  1. G. Divyashri
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  2. Pothiyappan Karthik
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  3. T. P. Krishna Murthy
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  4. Dey Priyadarshini
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  5. Kakarla Raghava Reddy
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  6. Anjanapura V. Raghu
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  7. Vinoth Kumar Vaidyanathan
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Contributions

GD prepared original draft, performed visualization and investigation. KRR conceived and designed the analysis, methodology and conceptualization. AVR and VVK contributed to the final version of the manuscript by editing and supervision. All authors read and approved the final manuscript.

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Correspondence to G. Divyashri or Vinoth Kumar Vaidyanathan.

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Divyashri, G., Karthik, P., Murthy, T.P.K. et al. Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives. Food Sci Biotechnol (2023). https://doi.org/10.1007/s10068-023-01381-3

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  • DOI: https://doi.org/10.1007/s10068-023-01381-3

Keywords

  • Prebiotics
  • Non-digestible oligosaccharides
  • Obesity
  • Beneficial microorganisms
  • Lipid metabolism and Glucose homeostasis