DSpace Collection: https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/432 2026-07-15T08:47:02Z 2026-07-15T08:47:02Z The Role of Catechol O Methyl Transferase Gene Variants in Modulating Labor Analgesia and anxiety—A Prospective Observational Study Shreedevi Kori . Vinithira Sri G V, Shivanand L. Karigar · Gurushantappa S. Kadakol · Rajasri Yaliwal · Neelamma Patil · Aruna Biradar https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/6297 2026-07-03T10:58:00Z 2026-03-01T00:00:00Z Title: The Role of Catechol O Methyl Transferase Gene Variants in Modulating Labor Analgesia and anxiety—A Prospective Observational Study Authors: Shreedevi Kori . Vinithira Sri G V, Shivanand L. Karigar · Gurushantappa S. Kadakol · Rajasri Yaliwal · Neelamma Patil · Aruna Biradar Abstract: Background Women experiencing labor pain undergo significant psychological and physiological challenges, often leading to increased rates of cesarean sections. Epidural analgesia has proven effective in managing labor pain, but its efficacy varies among individuals, partly due to genetic differences, including variations in the COMT gene, which influences pain perception pathways. Methodology Fifty-three hospitalized patients provided informed consent to participate in this study. Peripheral venous blood samples were collected in EDTA tubes for DNA isolation and Polymerase Chain Reaction (PCR) analysis to investi gate COMT gene polymorphisms. Epidural analgesia (Fentanyl with Ropivacaine) was administered upon reaching regular uterine contractions and cervical dilation of 4–5 cm. Pain and anxiety levels were assessed using the Visual Analog Scale (VAS) and State Anxiety Inventory (SAI) at predetermined intervals post-administration. Data analysis focused on exploring associations between COMT gene variants and outcomes related to pain perception and anxiety during labor. Results Of the 53 participants, 35 were homozygous for the wild-type genotype (Val/Val). Approximately 33.9% displayed COMT gene polymorphisms: 14 women were heterozygous (Met/Val) and 4 were homozygous for the Met allele (Met/Met). Women with the Met/Met and Met/Val genotypes reported significantly higher scores on the State Anxiety Inventory (SAI) and Visual Analog Scale (VAS) compared to those with the Val/Val genotype (p < 0.005). These women also required more supplementary analgesia during labor. Conclusion The presence of the Val158Met mutation in the COMT gene correlates with increased labor anxiety and reduced effec tiveness of analgesia in pregnant women. Understanding the genetic factors influencing pain perception could improve analgesic strategies tailored to specific genetic profiles, potentially promoting higher rates of vaginal deliveries and better birth experiences for women. Further research into genetic markers of labor analgesia is crucial for refining pain management approaches in obstetrics. 2026-03-01T00:00:00Z Successful management of uterine arteriovenous malformation causing post abortal bleeding: A rare case report Neelamma Patil, Devangam Nikhila, Gurubasava Sajjana, Santosh Arakeri, Shobha Shiragur and Syeda Atufiyat Amreen https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/6239 2026-06-25T04:25:48Z 2026-04-01T00:00:00Z Title: Successful management of uterine arteriovenous malformation causing post abortal bleeding: A rare case report Authors: Neelamma Patil, Devangam Nikhila, Gurubasava Sajjana, Santosh Arakeri, Shobha Shiragur and Syeda Atufiyat Amreen 2026-04-01T00:00:00Z Chlorhexidine-alcohol versus Povidone iodine plus Alcohol as Preoperative Antiseptic for Prevention of Surgical Site Infection in Caesarean Section: A Randomised Controlled Trial SHRAVANTHI SWAMY1, ARUNA M BIRADAR2, EKTA CHHABRA3, SHAILAJA RAJENDRA BIDRI4, NEELAMMA PATIL5, SHREEDEVI KORI6, SHILPA LAKSHMI7, PREETHI MALAPURE8 https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/6211 2026-06-05T03:52:40Z 2025-01-01T00:00:00Z Title: Chlorhexidine-alcohol versus Povidone iodine plus Alcohol as Preoperative Antiseptic for Prevention of Surgical Site Infection in Caesarean Section: A Randomised Controlled Trial Authors: SHRAVANTHI SWAMY1, ARUNA M BIRADAR2, EKTA CHHABRA3, SHAILAJA RAJENDRA BIDRI4, NEELAMMA PATIL5, SHREEDEVI KORI6, SHILPA LAKSHMI7, PREETHI MALAPURE8 2025-01-01T00:00:00Z Pregnancy with medical disorders: A prospective clinical study at a tertiary care hospital Monika Kanni, Aruna M Biradar, Neelamma Patil, Shreedevi Kori, Laxmi Sangolli and Preeti Malapure https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/6208 2026-06-03T10:43:32Z 2026-04-01T00:00:00Z Title: Pregnancy with medical disorders: A prospective clinical study at a tertiary care hospital Authors: Monika Kanni, Aruna M Biradar, Neelamma Patil, Shreedevi Kori, Laxmi Sangolli and Preeti Malapure 2026-04-01T00:00:00Z