DRESS syndrome secondary to pyrazinamide – A rare case report.

Abstract

Drug, rash, hypereosinophilia with systemic symptoms (DRESS syndrome) is life threatening drug induced hypersensitivity reaction. Pyrazinamide has been described as uncommon cause of DRESS syndrome. Here we report a 21 years old female patient had DRESS syndrome on 18th day of Pyrazinamide exposure. She had generalized pruritic maculopapular rash, fever, lymph node enlargement. Laboratory investigation revealed leucocytosis, eosinophilia, lymphocytosis, raised ESR, thrombocytopenia, raised liver enzymes. Urine examination revealed aseptic pyuria. She recovered completely 6 weeks after drug withdrawal. Here we report this as a rare case report of DRESS syndrome due to Pyrazinamide.