Serum Lipid profile and their ratios in patients with acute myocardial infarction: A Hospital based study.

Abstract

The post myocardial infarction care includes the management of dyslipidemia as one of the important aspects. There is a recommendation for the detection of dyslipidemia in patients within 24 hrs after infarction. It is also reported that the lipids ratio do contribute to assess the severity of myocardial infarction. The present study was undertaken with an objective to frame out the use of lipid profile and their ratios in patients with acute myocardial infarction.. The study included two groups; the first group consisted of 66 patients who were admitted to the hospital with Acute Myocardial Infarction (AMI). The second group consisted 50 normal healthy controls. Serum levels of CPK-MB and Lipid profile were assessed within 24 hours once the patients admitted to BLDE hospital, with the presentation of chest pain, which was suggestive of MI whose diagnosis of acute MI was made on patient history,symptoms, abnormalities with ECG findings.The patients with AMI had shown significant rise in CPK MB and the lipid parameters like High density lipoprotein (HDL) shown significant decrease and the Very Low Density Lipoprotein (VLDL) and triglycerides (TG) shown significant increase in cases compared to normal healthy individuals. Total Cholesterol (TC) and Low Density Lipoprotein (LDL) in cases did not show much difference in their respective values and were found to be statistically not significant. The ratios between different lipids show a significant variations compared to controls and were found to be statistically significant and also indicative of the severity of the infarction. The study suggests to consider the assessing of lipids ratios in normal subjects also as it is one of the atherogenic factor for the development of MI and other coronary complications.