Vitamin D influences Calcium Dependent Cardiovascular Functions with reference to NOS3 and VEGF

Abstract

Objective: To assess the link between vitamin D and cardiovascular diseases (CVD) in the percpective of angiogenic factors among the various types of CVD patients admitted in ICCU. Methods: Cross sectional study was conducted on CVD patients age ranging from 40 to 80 years who were diagnosed for first time and admitted in ICCU of BLDE(DU) Shri.B.M.Patil Medical College , Hospital and Research Centre Vijayapur ,Karnataka(India). The following parameters were tested: Anthropometric parameters: height (cms), weight (kgs), BMI (kg/m 2) and BSA (m 2); Physiological parameters: pulse rate in (beats/min), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), pulse pressure (mmHg) and mean arterial pressure (mmHg); Hematological parameters: RBC, WBC, HB%, PCV, Platelet count and blood indices like MCV, MCH, MCHC; echocardiography; electrocardiography; biochemical parameters: triglyceride, cholesterol, HDL, LDL, VLDL, serum creatinine, CPK-MB, serum sodium, potassium, calcium and vitamin D; Oxidative and nitrosative stress measure: serum malondialdehyde (MDA), nitric oxide (NOx) concentration; antioxidant capacity: serum superoxide dismutase (SOD) activity, and vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS3). Results: The increase in white blood cells (WBCs) level in present study indicate the inflammatory process in the physiological system. Further increase in the ESR is indicative of myocardial damage with leakage of proteins. As dyslipidemia is associated with various types of stress factors and MI, HHD and IHD are definitely generate more stress among all the types of CVD.Our results show significantly lower levels of vitamin D in all groups of CVD patients. Results also found higher levels of MDA , significantly lower levels SOD and lower

levels NO. We found decreased VEGF levels in present study in groups 3(IHD),4(Angina),6(RHD) and 7(Cardiomyopathy) and decreased levels of NOS3 in all groups of CVD patients Conclusion: Results clearly shows that vitamin D is an important factor for the regulation of cardiovascular health. Deficiency of vitamin D leads to most types of CVD in present study. Possibly vitamin D influences angiogenic factor like VEGF and alter cardiovascular remodeling. Further it may be concluded that the role of vitamin D induced cardiovascular remodeling depends on nature and types of CVD.