Faculty of Pediatricshttps://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/4192026-04-09T08:51:40Z2026-04-09T08:51:40ZEfficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled StudyAbbadi, Apoorva GayatriBijapure, Hidaytullah RDoddihal, Chandrika RPatil, Mallanagoudaprasannakumar, B Mhttps://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/56782025-01-11T06:34:11Z2025-01-01T00:00:00ZEfficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled Study
Abbadi, Apoorva Gayatri; Bijapure, Hidaytullah R; Doddihal, Chandrika R; Patil, Mallanagouda; prasannakumar, B M
Introduction: Scorpion sting is a serious health problem in the
world, especially in developing countries like India. It is often
associated with serious clinical manifestations. As children
have a small body surface area, they are prone to more serious
cardiac, respiratory and neurological complications. Prazosin,
an alpha-blocker, is the drug of choice for the treatment of
scorpion envenomation. With the increasing incidence of
paediatric scorpion envenomation in rural India, there is a need
to optimise prazosin dosing protocols to improve outcomes and
reduce hospital stays.
Aim: To evaluate and compare the efficacy and safety of
standard-dose versus high-dose prazosin protocols in managing
paediatric scorpion envenomation in a tertiary care hospital in
North Karnataka, India.
Materials and Methods: A single-blinded randomised controlled
study was conducted in Paediatric Intensive Care Unit (PICU) at
BLDE DU Shri BM Patil Medical College Hospital and Research
Centre, Vijayapur, Karnataka, India, from January 2017 to
December 2022. Children below 18 years of age admitted to
the hospital with history of scorpion sting with severity grades
II and III were enrolled. Children were randomised into three
groups: Group A: 30 µg/kg every three hours; Group B: 60 µg/
kg initially, followed by 30 µg/kg every three hours; and Group
C: 90 µg/kg initially, followed by 30 µg/kg every three hours.
They were monitored for sweating, cold or warm extremities,
the appearance and disappearance of pain, vital parameters
and priapism (in male children) hourly until stabilised, then every
third hourly for 24 hours and then sixth hourly til discharged
from the PICU. After the patient was haemodynamically stable
for 24 hours shifted to a high-dependency unit. The time interval
between sting and treatment, various vital parameters, duration
of the PICU stay and hospital stay were noted. Categorical
variables were compared using the Chi-square test and
continuous variables were analysed using the Student’s t-test.
Results: A total of 86 children were recruited. The standard
protocol (Group A) had 26, Group B had 29 and Group C had 31
children. Forty-eight (56%) of the children were over five years
old (12, 21 and 15 were in Groups A, B and C, respectively).
The male-to-female ratio of 1.8:1, 2.6:1 and 1.8:1 in Groups A,
B and C, respectively. The sting-to-symptom interval, priapism,
duration of hypertension and duration of hospital stay were
higher in Group B compared to Group A. The duration of
hypertension, cardiac involvement and priapism were higher
in Group C, whereas a shorter sting-to-symptom interval and
symptom-to-prazosin initiation were noted in Group C compared
to Group A.
Conclusion: High-dose prazosin is a safe and effective
treatment for scorpion envenomation in children, offering a
potential advantage over the standard dosing protocol.
2025-01-01T00:00:00ZAssessing the bite time to needle time and its correlation with mortality and morbidity in subjects with snake bite.Annasaheb Jyotiram Dhumale, Rakesh Balamkar, Anurag Jain, Mahesh Gupta.https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/56402024-11-14T10:44:56Z2023-01-01T00:00:00ZAssessing the bite time to needle time and its correlation with mortality and morbidity in subjects with snake bite.
Annasaheb Jyotiram Dhumale, Rakesh Balamkar, Anurag Jain, Mahesh Gupta.
2023-01-01T00:00:00ZPulmonary vasodilator therapy in neonates with hypoxic respiratory failure - a prospective cohort study.Deepa Kundargi, Vijayakumar Biradar, Siddu Charki, M M Patil.https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/56392024-11-14T10:40:19Z2024-01-01T00:00:00ZPulmonary vasodilator therapy in neonates with hypoxic respiratory failure - a prospective cohort study.
Deepa Kundargi, Vijayakumar Biradar, Siddu Charki, M M Patil.
2024-01-01T00:00:00ZMalondialdehyde as a Prognosticating Marker for Staging of HIE - A Prospective Cohort Study.Lavanya Pidikiti, Anilkumar Sajjan, Raghavendra H. Gobbur, Siddu Charki, Vijayakumar Biradar, M.M. Patil.https://digitallibrary.bldedu.ac.in/xmlui/handle/123456789/56382024-11-14T10:38:27Z2024-01-01T00:00:00ZMalondialdehyde as a Prognosticating Marker for Staging of HIE - A Prospective Cohort Study.
Lavanya Pidikiti, Anilkumar Sajjan, Raghavendra H. Gobbur, Siddu Charki, Vijayakumar Biradar, M.M. Patil.
2024-01-01T00:00:00Z