Department of Physiology

Influence of Vitamin D on Arterial Stiffness in Hypertensive Patients with Special Reference to Oxygen Sensing Protein Expression

2020-01-01T00:00:00Z

Influence of Vitamin D on Arterial Stiffness in Hypertensive Patients with Special Reference to Oxygen Sensing Protein Expression Podder, Amrit

A Comparative Study Of Pulmonary Function Tests In Obese & Non Obese Students In The Age Group Of 18-25 Years

2015-01-01T00:00:00Z

A Comparative Study Of Pulmonary Function Tests In Obese & Non Obese Students In The Age Group Of 18-25 Years Sowmya Timmanna, Koraddi Background & objective: A study was conducted to determine the effect of obesity on pulmonary functions and to compare the same between obese and non obese students in the age group of 18-25 years. Material & methods: A cross sectional study was conducted on obese (BMI ≥ 30 kg/m2) male (n=32) and female (n=18) students aged 18-25 years and compared with age matched non-obese (BMI 18.5–24.99 Kg/m2) male (n=23) and female subjects (n=27) as control. Detailed anthropometric and physiological data were collected. Pulmonary functions were recorded by using Computerized Spiro excel. Parameters recorded were Forced Vital Capacity (FVC in ml), Forced Expiratory Volume in 1st sec (FEV1 in ml), FEV1 %, Peak Expiratory Flow Rate [PEFR in L/min was recorded by mini Wright’s Peak flow meter] and Maximum Expiratory Pressure [MEP in mmHg was recorded by Modified Black’s apparatus]. Statistical analysis was done by calculating MeanSD by using student’s t test. Correlation between degree of obesity and pulmonary functions was done by Pearson’s correlation Results: Systolic Blood Pressure, Diastolic Blood Pressure, Pulse Rate and Respiratory Rate were significantly higher in obese students when compared to their respective control. We observed highly significant reduction in PEFR (p<0.001) and MEP IX (p<0.001) in both obese male and female subjects compared to control. FEV1% was significantly lower in obese female students. In present study, FVC and FEV1 were negatively correlated with adiposity markers (BMI, WC, WHR, WHtR, Body fat %). WC {FVC (r = -0.253, p< 0.01), FEV1 (r = -0.236, p < 0.05)}, WHtR {FVC(r = -0.357, p< 0.001) and FEV1 (r = 0.319, p < 0.01)} were statistically significant with FVC. Significant negative correlation of PEFR and MEP was observed with all adiposity markers. Interpretation & conclusion: The study concludes that all the respiratory parameters were significantly reduced in obese subjects compared to non-obese subjects. Obesity and pattern of fat distribution have independent effect on pulmonary function

A Study Of Effect Of Age On Cardiovascular Autonomic Function Tests In Healthy Subjects Of B.L.D.E.A’s Shri B.M.Patil Medical College, Bijapur

2010-01-01T00:00:00Z

A Study Of Effect Of Age On Cardiovascular Autonomic Function Tests In Healthy Subjects Of B.L.D.E.A’s Shri B.M.Patil Medical College, Bijapur Shrilaxmi, Bagali Background & Objectives: Ageing is a physiological process. With advancement of age there is a progressive declination of almost all bodily functions including autonomic nerve function. Thus this study was designed to evaluate the effect of ageing on cardiovascular autonomic function in healthy subjects. Methods: The autonomic function tests analyzed were Valsalva maneuver, Heart rate response to deep breathing, Heart rate response to standing, Blood pressure response to standing, Blood pressure response to Sustained Hand Grip in 152 healthy subjects in the age range of 18-65 years of BLDEA’S Shri B M Patil Medical college Bijapur. The subjects were divided into four groups according to age (Group I 18-19 years, Group II 20-34 years, Group III 35-54 years, Group IV 55-65 years). The various autonomic function tests were graded by using Ewing & Clarke scores. Unpaired Student’s t-test, One Way ANOVA, Pearson correlation were used for statistical analysis. Results: The following variations observed were statistically significant: 1) Valsalva maneuver gradually decreased from 1.50 + 0.37 (Group I) to 1.24 + 0.18 (Group IV) 2) HR response to deep breathing gradually decreased from 24.23 + 5.46 bpm (Group I) to 10.40 + 7.65 bpm (Group IV) 3) HR response to standing gradually decreased from 1.30 + 0.18 (Group I) to 1.12 + 0.15 (Group IV) 4) BP response to Sustained Hand Grip gradually decreased from 26.37 + 9.24 (Group I) to 13.29 + 4.79 (Group IV). X BP response to standing showed an insignificant increase in SBP (8.9 + 3.04 to 13.29 + 4.79) on standing as age advances. All these parameters except BP response to standing were negatively correlated with age & these relationships were statistically significant. Parasympathetic, Sympathetic & Total autonomic function score showed gradual increase in the abnormal score as age advances in both sexes. Interpretation & Conclusion: 1) Autonomic function tests showed gradual decrease in function as age advances in both sexes (18-65 years) in different age groups. 2) Heart rate variation during deep breathing (r= -0.635) & Blood pressure response to Sustained Hand Grip (r= -0. 516) appear to be more sensitive parameters amongst the three Parasympathetic function tests & the two Sympathetic function tests respectively 3) There is a gradual increase in the abnormal autonomic function score of both sexes as age advances in different age groups. 4) Parasympathetic & Sympathetic function tests showed more decline in females as compared to males of the same age group.

Effect Of Type 2 Diabetes Mellitus On Dynamic Pulmonary Function Tests

2010-01-01T00:00:00Z

Effect Of Type 2 Diabetes Mellitus On Dynamic Pulmonary Function Tests Gouher Banu.U., Shaikh Background & objective: The purpose of this study was to evaluate pulmonary functions in patients with type 2 diabetes mellitus and to determine their correlations with anthropometric profile, glycaemic control, and duration of diabetes. Material & methods: Forty type2 diabetic patients, aged 30-60years, with diabetic duration of 1-20 years, were included in the study. Type2 diabetic patients were taken from Diabetic clinic of B.L.D.E.A.’s Shri B. M. Patil Medical College, Hospital and Research Centre, Bijapur, by applying inclusion & exclusion criteria using random sampling method. Detailed anthropometric and physiological datas were collected, spirometry was performed and Forced vital capacity (FVC), Forced expiratory volume in 1 second (FEV1), & FEV1% are recorded. Peak expiratory flow rate (PEFR) and Maximum expiratory pressure (MEP) were recorded by Wright’s Peak flow meter & Modified Black’s apparatus.. And the results were compared with age and sex matched control (non diabetic) subjects, taken from teaching & non teaching staff of B.L.D.E.A.’s Shri B. M. Patil Medical College, Hospital and Research Centre, Bijapur. Results were analysed by calculating Mean±SD, using Student’s t test, and Pearson correlation.