Abstract:
Malondialdehyde (MDA) cause toxic stress in cells and form covalent protein and its used as a
biomarker to measure the level of oxidative stress. There is opposite mechanism which control the flux of
reactive oxygen species (ROS) called as antioxidant system, which includes both enzymatic andnon-enzymatic
components. The important enzyme of this system is superoxide dismutase (SOD). The black cumin or Nigella
Sativaseeds are used in traditional medicine of different countries. Thymoquinone is major bioactive component
of nigellasativa seed and it is the cause of therapeutic property of Nigella sativa seed. The present study is
conducted to see the effect of Nigella Sativa seed powder and Thymoquinone on Serum MDA and SOD levels in
normal and Streptozotocine Induced Diabetic Rats.
