Influence of α-tocopherol on blood glucose regulation of alloxan induced male diabetic rats exposed to nickel sulfate.

Abstract

Introduction: There is growing evidence that oxidative stress contributes to the pancreatic islet P-cell destruction in diabetes. It seems that nickel induces glucose deregulation through reactive oxygen species (ROS) pathway. Since vitamin E is known to protect the cells from oxidative damage due to its potent antioxidant properties.