Abstract:
Background: C-peptide is produced in equimolar
concentration during insulin production as inactive
molecule by beta islet cells of Langerhans. C-peptide
is most useful biomarker of endogenous insulin
production. Aim and Objectives: To predict metabolic
syndrome in advance by estimation of C-peptide and
lipid profile in healthy adults. Material and Methods:
Serum C-peptide, fasting blood glucose and lipid
profile of 128 healthy individuals were estimated.
Adults in the age group of 18 to 60 years of both sexes
were included in study. Results: C-peptide levels were
increased in 27%, Serum cholesterol in 30%, LDL
Cholesterol in 55% and triglyceride levels in 21% of
healthy individuals. Significant correlation was
observed between C peptide, age, serum cholesterol,
LDL and cholesterol LDL ratio in male subjects only.
In our study group most of the subjects (both males and
females) fell in overweight group. Conclusion: Cpeptide
level and lipid profile may be considered as
useful biomarkers to predict type 2 diabetes mellitus in
advance, possibly due to insulin resistance.
