Abstract:
Skin and soft-tissue infections (SSTIs) are the most frequent forms of the disease. S. aureus is capable of causing a
wide range of infections including skin infections, abscesses, toxic shock and scalded skin syndrome. The current
study was undertaken to know the Antibiotic resistance of S. aureus causing SSTIs, isolated from patients attending
the OPD of our tertiary care hospital. Pus samples were collected from patients presenting with ailments like
abscesses, carbuncles, osteomyelitis and skin infections at our hospital OPD from June 2012 to June 2014. S.
aureus was identified by conventional techniques. Antimicrobial susceptibility testing of the isolates were be
performed by Kirby Bauer disc diffusion method . The data were recorded and analyzed at the completion of the
study as per recommendations of the CLSI. During the study period a total of 50 isolates of S. aureus were isolated
from SSTI infections in patients visiting OPDs. Among these 31 were isolated from male patients .Majority of the
isolates were from (74%) were deep abscesses, were isolated were from middle age group of 20- 50 years age.
Anti-biograms of S. aureus isolates revealed high level of resistance to penicillin, pefloxacin amoxicillin/clavulanic
acid. The most effective agent against S. aureus isolates were linezolid, piperacillin/tazobactam followed by
tetracycline. The current study revealed that majority of the isolates were from were deep abscesses, Anti-biograms
of S. aureus revealed high level of resistance to penicillin, pefloxacin amoxicillin/clavulanic acid . The most
effective agent against S. aureus isolates were linezolid, piperacillin/tazobactam followed by tetracycline
