Abstract:
Background & Objectives:
This was a prospective study to estimate the Serum Lactate levels and as a
prognostic marker in patients with Sepsis. To estimate the serum lactate values at the
time of admission and the second sample value at 24-48 hrs after admission and to
predict the outcome of patients with sepsis based on serum lactate levels and its
clearance.
Methods:
This study consists of 170 selected cases patients admitted with sepsis
condition in B.L.D.E.U s Shri. B. M.Patil Medical College, Hospital and Research
Centre, Vijayapur from October 2014 to June 2016.
Results:
In thisstudy the mean serum lactate value of first sample in survivors (146
patients) is 3.8 ± 1.2 and nonsurvivors(24 patients) is 6.2 ±1.9 with p value <0.001
which is significant. The serum lactate value of the second sample in survivors(146) is
2.7 ±1.0 and in nonsurvivors(24) is 6.3±1.8 with p value <0.001 which is
significant.The mean value of serum lactate 1st sample collected at the time of
admission is 4.1±1.6 and the mean value of serum lactate second sample collected at
24-48 hrs after admission is 3.1±1.6.Highly significant difference is there between
serum lactate 1st and 2nd sample with p value <0.001 which is significant.Hence serum
lactate is considered as a prognostic marker in patients with sepsis and evaluates the
treatment outcome.
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Interpretation and Conclusion:
Fall in lactate concentration following the initiation of treatment for sepsis is
due to an attenuation of the stress response. Lactate levels are one of the most used
biomarkers in sepsis. When their level is more than 4 mmol/L patients are at highest
risk of mortality and an aggressive resuscitation strategy shall be warranted.This
study suggests an important role for serial sampling of the subsequent two lactate
values and lactate clearance as a prognostic indicator of sepsis.Patients with initial
serum lactate value >4.0 mmol/L were independently associated with mortalityand
serum lactate had a positive correlation with outcome of sepsis.Hence serum lactate is
considered as a independent and significant prognostic marker in patients with sepsis
