Smokeless tobacco induced effect on biochemical parameters levels in type-2 diabetes mellitus subjects.

Abstract

Diabetes mellitus is characterized by uncontrolled hyperglycemia, which leads to life threatening complication and may result from acute metabolic aberrations. Prevalence any kind current use of tobacco on average is 29.4% and 15.5% smoking and 13.9%smokeless.(ICMR prevalence survey data in Karnataka 2001) WHO 2011 report, 6 million people die every year is due to nicotine toxicity2. Hence research is planned to establish possible relation between the levels plasma Uric Acid, MDA, Amylase level with Lipid profile in (ST) tobacco user in type 2 diabetic subjects as compared with Non ST tobacco user Diabetic Subjects in Northern Karnataka Population with their Demographic life style of 62 diabetes patients and normal subjects attending BLDE University’s Sri B.M.Patil Medical College Hospital for routine checkup. The results show significant alteration of lipid profile and uric acid levels (P<0.001) tobacco user Diabetes and Free radical MDA generation P>0.001 but not much alteration in serum Amylase. In this study positive correlation between Blood Glucose, serum MDA and Uric Acid levels indicating pre diabetic markers and early diabetic complication.