Safety And Efficacy Of Low Dose Intravenous Ketamine In Labour Analgesia,A Single Blinded Randomized Controlled Trial

Abstract

INTRODUCTION Most primary and secondary level hospitals in developing countries provide inadequate labor analgesia due to various medical technical and economic reasons. This clinical trial was an effort to study the efficacy, safety, and feasibility of low dose intravenous ketamine in labor analgesia. The phencyclide derivative Ketamine is widely used as IV and IM anesthetic agent and is mediated through opiate receptor and N-methyl D-asparate receptors. A systemic administration of ketamine produce a obvious advantage over nacrotics in which major drawback is respiratory depression. AIM AND OBJECTIVES To study the efficacy of Ketamine in labor analgesia in following parameters. 1.Maternal outcome in form of duration & mode of delivery, complication of 3rd stage of labor. 2.Fetal outcome inform of APGAR score. 3.To evaluate patient satisfaction about this method. MATERIALS AND METHODS A total of 120 parturients were consented and randomly assigned to receive either IV ketamine or 0.9%NS. A loading dose of 0.2mg/kg over 30mins following by an infusion of 0.2mg/kg/hr until delivery of the baby. The control group will be infused with NS with similar volumes.