Study Of The Effectiveness Of Oral Clonidine And Oral Pregabalin In Attenuating The Hemodynamic Pressor Response During Laryngoscopy And Tracheal Intubation

Abstract

Background and objectives: Laryngoscopy is a noxious and most invasive stimulus before endotracheal intubation.Manipulation of the respiratory tract such as during laryngoscopy and endotracheal intubation are associated with cardiovascular responses consisting of increased circulating catecholamines, raised heart rate and blood pressure, increased myocardial oxygen demand, and possible dysrhythmias. This study was carried out to compare the effect of oral Clonidine and oral Pregabalin premedication with respect to hemodynamic variables like HR, SBP, DBP, MAP and RPP in attenuating the hemodynamic stress response following laryngoscopy and endotracheal intubation. Methods: A prospective, randomized study was conducted on 90 adult consented patients aged 18 to 60 yrs with ASA I or II of either sex scheduled to undergo elective general surgical procedures under general anaesthesia, were randomized to receive Clonidine (300mcg) Group C, Pregabalin (75mg) Group P given 120 minutes before surgery as oral premedication. Anaesthetic technique was standardized and both groups were compared for the haemodynamic changes before study drug, after study drug administration at 30min, 60min, 90min, before induction, after laryngoscopy and intubation at 1min, 5min, 10min and 15min. Results: In this study, it was observed that Clonidine was found to be better than Pregabalin in lowering of systolic blood pressure, diastolic blood pressure, mean arterial pressure,rate pressure rate and heart rate changes associated with laryngoscopy and intubation. None of the premedicated patient has suffered from any postoperative side effects Conclusion:. Oral premedication with Clonidine 300μg was superior to Pregabalin 75mg resulting in hemodynamic stability during laryngoscopy and endotracheal intubation.