Abstract:
AIMS & OBJECTIVES:
To evaluate D-dimer levels in predicting the severity of acute pancreatitis .To evaluate the ability
of the D-dimer to assess early development of organ failure.
MATERIALS AND METHODS:
This is a prospective observational study of 115 patients presented with Acute Pancreatitis in
B.L.D.E (DU)’S Shri B.M.Patil Medical College and the D-dimer values for these patients were
measured on day 1, 3, 5.
RESULTS:
Out of 115 patients of acute pancreatitis 31-40 years age group was predominant (20.6 %).
Majority were the male patients (91.3%) in the study. Gall stones is the major etiological factor
observed in the patients (62%).
Age of the total patient was compared with raised d-dimer values using spearman’s and was
considered significant. Common modes of presentation in this study were pain abdomen (85%),
vomiting (27%). D-dimer values measured on admission day and subsequently on day 3 and 5
showed increased association with acute pancreatitis, as well as predicted early the occurrence of
organ failure.
Diagnostic accuracy and ROC analysis of D-dimer score was compared with the remaining three
scoring systems that is APACHE 2, SOFA, Ranson’s score were (p less than 0.001).
It has a sensitivity of 94% and specificity of 86.2%. This is much higher than the sensitivity and
specificity compared with other three studies.
CONCLUSION:
D-dimer value is a useful tool for Diagnosis of acute pancreatitis as well as predicting the
occurrence of organ failure early.
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