Abstract:
ABSTRACT
Introduction –
Prostate cancer accounted about 1,276,106 new cases and 358,989 deaths which is
around 3.8% of deaths in men with cancer during the year 2018.
The gold standard for the diagnosis of prostatic carcinoma is light microscopic
findings, although there are complicated cases which would benefit from
immunohistochemical studies. Recently studies have revealed the role of estrogen
signaling pathways in the carcinogenesis of prostate. It is noted that there is wide
variation in results of various studies regarding the expression of ER β with respect to
grade of tumor in prostate carcinoma. There is need of additional research to
standardize distribution of this receptor in human prostatic tissue. This will be useful
in synthesizing the understanding of its role in regulation of prostate epithelial cell
proliferation at various stages in lifecycle of prostate carcinoma.
