Genetic and Molecular Profiling of FIX (FACTOR 9) Gene of Hemophilia B in Karnataka

Abstract

Bleeding disorders are one of the rare genetic disorders which are characterized by persistent or increasing bleeding. Hemophilia is one of many diseases in the category of hereditary bleeding disorders (1). Hemophilia is characterized by abnormal or excessive bleeding. Hemophilia has been a Royal disease for its effect on the Royal family of Europe. Two of Queen Victoria's daughters were carriers for the disease and passed the defective gene to other Royal families, including that of Leopald, who had haemophilia, and other members of the family (2).