Abstract:
The neuromuscular blocking agent plays an essential role in balanced anaesthesia,
and the introduction of skeletal muscle relaxants has revolutionised the field of
anaesthesia and critical care. In the operation theatre, skeletal muscle relaxants
are used for two purposes: one is to do endotracheal intubation, and another
purpose is to give relaxation during surgery. Atracurium and cisatracurium,
intermediate acting, benzylisoquinolone Non depolarizing neuromuscular
blocking agents, are used for endotracheal intubation when there is a
contraindication for succinylcholine. These drugs have fewer side effects, and
organ-independent elimination has made it the most commonly used
neuromuscular agent. The present study is designed to evaluate the adverse drug
reactions and economic benefits of both drugs.
MATERIALS AND METHODS:
This study included 140 patients scheduled to undergo elective surgery under
general anaesthesia with endotracheal intubation and required intraoperative
neuromuscular blockade. The study subjects were randomly split into two groups
of 70 each.
Group A: 70 patients receiving Atracurium 0.5mg/kg
Group B: 70 patients receiving cisatracurium 0.15mg/kg
Atracurium and cisatracurium were given to the patients just before endotracheal
intubation and were assessed for adverse drug reactions and cost benefit between
both drugs RESULT
The hemodynamics like MAP, PR, SPO2, ECG, other clinical features, adverse
reactions, and the drug's cost were assessed. In terms of side effects, both drugs
provide similar safety profiles, and cisatracurium is slightly a safer drug as it does
not cause much hemodynamic changes and nil histamine release and can safely
used in asthma and other histamine related disorders. In terms of cost comparison,
Atracurium has economic benefits than cisatracurium
CONCLUSION
Both drugs have a similar safety profile, and cisatracurium is a better choice for
patients with hemodynamic instability and those with a risk of histamine related
disorders like asthma and anaphylaxis. In terms of economic benefit, atracurium
is a better choice.
