A CLINICAL STUDY OF URINARYALBUMIN TO CREATININE RATIO INCRITICALLY ILL PATIENTS

Abstract

INTRODUCTION: ‟In Critical care units, prediction of outcome is of vital importance to the clinician. It allows planning of early therapeutic intervention and appropriate counseling of patient. Prognostic measures used in ICU should ideally detect short term changes in critical illnesses and also reflect impact of early therapeutic interventions on the outcome of patient. So sensitive, inexpensive and dynamic prognostic markers which generate rapid and reliable results are therefore desirable in the ICU settingʼʼ. OBJECTIVES: 1. To evaluate Urinary albumin to creatinine ratio within 6 hours of ICU admission and after 24 hours of ICU admission. 2. To correlate Urinary albumin to creatinine ratio with APACHE II score,SOFA score to predict outcome in critically ill patients. METHOD: In this prospective non-interventional study, 98 adult patients admitted to I.C.U. with more than 24 hours of ICU stay were included and after their informed consent, blood and urine samples were collected on admission to ICU and 6, 24 hours thereafter Spot urine sample collected at 6, 24 hours of admission to medical ICU ward. Sample will be tested for urine microalbumin by immunoturbidometric method and urinary creatinine was measured by calorimetric method. Albumin: creatinine ratio was measured. For disease prognosis scoring, GCS, SOFA and APACHE II scores were calculated simultaneously.