CORRELATION OF HbA1C LEVELS WITH CLINICAL PROFILE AND INFARCT SIZE IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Abstract

BACKGROUND: Stroke is the second leading causes of death worldwide and one of the leading causes of disability. The most common cause of stroke is represented by cerebral ischemia and approximately 80% of strokes are due to ischemic cerebral infarction and 20% due to brain hemorrhage. Diabetes Mellitus is an independent risk factor for stroke and is associated with 2 to 6 fold increased risk compared with non-diabetic subjects and worsens survival of patients with acute stroke. AIMS AND OBJECTIVES: To correlate the HbA1C levels with clinical profile and infarct size in patients with Acute ischemic stroke. MATERIALS AND METHODS: This Cross sectional study was conducted in the Department of Medicine, Shri B M Patil medical college hospital and research centre, Vijayapura in patients with acute ischemic stroke. A study design consists of 64patients. Age >18 years and patients with Acute ischemic stroke has been included in this study. RESULTS : Maximum number of patients were in the age group of 60 – 69 years, with mean age of 63.59±12.59 years. There were 25 patients (39.1%) well controlled Diabetes patients,16(25.0%) fairly controlled and 23 (35.9%)were poorly controlled Diabetic patients. Progressive increase in the NIHSS score from well controlled diabetes to poorly controlled diabetes. The NIHSS score increased as the infarct size increased from well controlled to poorly controlled diabetes. Increased severity of stroke is seen in poorly controlled diabetes which correlates with the infarct size. x CONCLUSION: HbA1c levels, NIHSS score correlates well with the infarct size. Severity of the stroke worsened from well controlled diabetes to poorly controlled diabetes.HbA1c should be considered as an independent risk factor for poor clinical outcome and worse prognosis,