Abstract:
Diabetes mellitus is the most common endocrine disease characterized by
metabolic abnormalities, hyperglycemia and by long term complications. Large
platelet are younger, more active and aggregable, have dense granules, secrete more
proaggregatory molecules. Platelet activation contributes to trigger thrombus
formation and causing microcapillary embolization. Platelet is directly regulated by
insulin via functional insulin receptor found on human platelets. Insulin inhibits
platelet interaction with collagen and attenuates the platelet aggregation effect of
agonist in healthy platelets. MPV, a determinant of platelet function, is a newly
emerging risk factor for atherothrombosis. Increased in HbA1c concentration is
directly proportional to increased MPV. MPV can emerge as an important, simple,
effortless, and cost-effective tool for monitoring and for early recognition of patients
that could possibly benefit from preventive treatment.
