Correlation of fibrinogen-albumin ratio with gensini score in st-segment elevation myocardial infarction

Abstract

Background & Objectives: Coronary Artery Disease (CAD) is one of the leading causes of morbidity and death in the globe. The most dangerous kind of CAD is acute ST-segment elevation myocardial infarction (STEMI). In reaction to systemic inflammatory and

hemorheology changes, fibrinogen is a crucial component. A key mediator of platelet- induced coronary artery constriction is albumin. Hypoalbuminemia can change

endothelial function and raise blood viscosity. Additional information may be provided by the fibrinogen-albumin ratio (FAR), which addresses the pathophysiology of STEMI. The aim of this study is to calculate FAR in STEMI patients and compare FAR to the Gensini score (GS) derived from coronary angiography (CAG).

Materials & Methods: 70 STEMI patients were participated in this cross-sectional study that lasted for one and a half years, from May 2023 to December 2024. In accordance with the structured proforma, eligible patients for percutaneous coronary intervention had a clinical history, physical examination, and investigations. Frequencies and proportions have been used to represent categorical data. For qualitative data, the chi-square test, also known as Fischer's exact test, was employed as a significance test. The Pearson Correlation coefficient was used to perform correlations. Using the Gensini scoring method, we assessed the degree of coronary artery disease. There was a correlation between the Gensini score and FAR readings. Statistical significance was defined as a P-value of less than 0.05. Docusign Envelope ID: 03A5DFF4-9C10-4D26-A0ED-A86C500037B5

XII

There were 23 (32.9%) females and 47 (67.1%) males in this study. 20 (28.6%) had triple vascular disease (TVD), 24 (34.3%) had double vessel disease (DVD), and about 24 (34.3%) had single vessel disease (SVD) and 2 (2.9%) were recanalized . FAR and Gensini score had a negative correlation (Pearson correlation; r = -0.02). This correlation was not statistically significant. Gensini score had a positive correlation with severity of coronary artery disease. Interpretation & Conclusion: Fibrinogen and albumin have negative relationships with GS, although FAR may not be a replacement for coronary angiography in assessing the severity of CAD. It is a practical, non-invasive test that can be performed in a primary or secondary healthcare facility. This is done in order to determine which patients are more likely to experience cardiovascular events and to start taking the necessary precautions.