Abstract:
BACKGROUND: Preterm prelabour rupture of membrane(PPROM) accounts
for 2-3% of all complicated pregnancies and is one of the major causes of
preterm deliveries. AIM AND OBJECTIVE:To evaluate and compare maternal and neonatal
outcomes in women with PPROM treated with prophylactic antibiotics for 7
days versus until delivery.
MATERIALS AND METHOD:A total of 110 pregnant women of 26 weeks 0
days to 36 weeks 6 days gestation diagnosed with PPROM receiving
prophylactic antibiotics for 7 days(Group1) and until delivery(Group2) were
included in study. Details regarding the duration of ROM, prophylactic
antibiotics used were recorded. Both maternal and neonatal outcomes were
assessed and analyzed.
RESULTS:There was a notable difference in the incidence of persistent
amniotic fluid leakage between the two groups. 56.3% of patients who received
a 7-day antibiotic treatment experienced active leakage and 81.8% was seen in
the antibiotics-until-delivery group. This difference was found to be statistically
major(p<0.002). CPAP was not required in 74.5% of Group1 and 72.7% of
Group2. A larger number of newborns of Group1 needed HFNC support
compared to Group2(p=0.015). 72.7% of Group1 didn’t need O2 hood and
83.6% in Group2. There was a notable difference between the two groups(p =
0.037; χ2 = 6.6, df = 2), suggesting that how long the antibiotics are given might
impact needing oxygen support in neonates. 52.7% needed hospital stay for 1-3
days, in Group1 and 30.9% in Group2 with a statistical significance of (p =
0.048).
CONCLUSION: A 7-day course of prophylactic antibiotics treatment in
PPROM is as effective as continued therapy until delivery with benefits of
reduced hospital stay and antibiotic associated risks.
